Topical Presentation:
Natural Product Synthesis through Template-Directed C-H Bond Insertion Reactions: Approaches to the Synthesis of Zaragozic acid A and Mycestericin D
 
Speaker: Prof. Duncan J. Wardrop
Assistant Professor, University of Illinois at Chicago
Date: Friday, February 25, 2000
Location:   Elmhurst College Science Center
(minutes from dinner at the Diplomat West)
190 Prospect Avenue
Elmhurst, IL 60126
Times:
Topical Group: 5:00-6:00 P.M. (note earlier time)
Social Hour: 6:00- 7:00 P.M.
Cash Bar Available
Dinner: 7:00 P.M.
Meeting: 8:00 P.M.

Speaker:

Prof. Duncan J. Wardrop
Assistant Professor, University of Illinois at Chicago

Biography:

BSc (Honors) Glasgow University 1991
Ph.D. Glasgow University 1994
Postdoctoral Oregon State University 1995-1997

Abstract:

During the last two decades, the dirhodium(II)-catalyzed intramolecular insertion of metal carbenes into unactivated C-H bonds has emerged as a particularly powerful method for the construction of both carbocyclic and heterocyclic systems. Recent work from our laboratory has uncovered a novel method for the simultaneous desymmetrization and functionalization of meso-1,3-diols utilizing a C-H bond insertion reaction. We are currently applying this strategy to the synthesis of a diverse range of biologically relevant target molecules, including the antihypertensive agent zaragozic acid A and the potent immunosuppressant mycestericin D.

Directions:

FROM CHICAGO: Take Interstate 290 west to St. Charles Road West and proceed to Prospect Avenue. Turn right on Prospect Avenue. The Science Center with parking is on the corner of Prospect and Church.

FROM THE SOUTH: Take Interstate 294 north to Interstate 290 West (to Rockford) and follow directions above.

FROM THE NORTH: Take Interstate 294 south to the exit marked "I-290 West/ U.S. 20-Lake/ Ill. 64- North Avenue". Exit immediately at "Ill 64-North Avenue" and proceed west approximately 1.5 miles to Maple Avenue. Turn left on Maple Avenue proceed across the tracks to the camput. (Maple Avenue becomes Prospect Avenue south of the tracks. The Science Center with parking is on the corner of Prospect and Church.



Updated 1/23/00