January 2002 Meeting
 
Speaker:   Dr. Phyllis Bowen
Dept. of Human Nutrition
College of Applied Health Sciences
University of Illinois at Chicago
Topic:   "Modulation of Biomarkers of Carcinogenesis by Tomato Sauce Feeding in Men with Prostate Cancer"

Phyllis Bowen Abstract:     As part of a larger study to evaluate the effect of lycopene supplementation on DNA damage in men with prostate cancer or high serum PSA concentrations, a non-randomized 5th arm using tomato sauce was included. This portion of the study has been completed and the results analyzed before and after tomato sauce supplementation. Thirty-two patients with localized prostate adenocarcinoma consumed tomato sauce- based pasta dishes for 3 wks (30 mg lycopene/d) before their scheduled radical prostatectomy. Serum and prostate lycopene concentrations, serum PSA, leukocyte DNA 8-OH-deoxyguanosine/deoxygguanosine(8OHdG) was measured at baseline and at the end of the intervention. Resected prostate tissue DNA 8OHdG from the study participants and 7 randomly selected prostate tissues from a control group were also evaluated. Cancer cells in paraffin sections of prostate biopsies and post-intervention resected tissue were compared for 8OHdG staining using a monoclonal antibody for 8OHdG. Adherence to the daily consumption of tomato-based entrees was excellent and serum and prostate lycopene concentrations increased 1.97 and 2.92 fold(p<0.001) respectively. Mean serum PSA concentrations decreased by 17.5% (p<0.002) and leukocyte 8OHdG decreased by 21.3% (p<0.005) after tomato sauce consumption. Study participants, at the time of resection, had 28.3% lower prostate 8OHdG concentrations compared to controls. (p<0.03). The amount of oxidative damage to nuclear DNA in prostate cancer cells was greatly reduced by assessment of two pathologists and by mean nuclear density (40.5%, p<0.005) and mean area(36.4%, p<0.018) staining. Apoptotic index was increased in tumor and hyperplastic tissue. These data taken as a whole indicate good uptake of lycopene into prostate tissue and a reduction in DNA damage in both leukocytes and prostate tissue. Whether reduction in DNA damage to prostate cancer cells is beneficial awaits further research.

Biography:     Dr. Bowen received her Ph.D. in Nutrition from Cornell University as well as her M.S. degree. She received a B.S. degree from Iowa State University in Food Science. She was a faculty member in the Department of Human Foods and Nutrition at Virginia Polytechnic Institute and State University for 6 years and has been part of the faculty of the Department of Human Nutrition and Dietetics at the University of Illinois for 17 yrs and is currently Associate Professor. She has held various Departmental assignments including Acting Head, Associate Head, Director of Graduate Studies and Coordinated Undergraduate Program Direction and Director of the Nutrition and Metabolism Laboratory. She has received several teaching awards for her undergraduate and graduate teaching. She was founding member and was associate director of the Functional Foods for Health Research Program, a joint campus program of the University of Illinois with over 90 faculty members and 28 industrial affiliates. She headed the clinical trials that formed the basis of the Ensure plus Fiber nutritional formulas and reformulation of Regular and Ensure plus Fiber (Ross Products Div, Abbott Labs). She is internationally known for human metabolism/function studies on carotenoids, lipids, and vitamin E with over 65 publications in the field. She is founding member and past chair of the Carotenoids Interaction Research Group which has an international mailing list of 400 scientists and is on the founding steering committee for the International Carotenoids Society. She has served on the Council for Research and Chair of the Research Dietetics Practice Group in the American Dietetics Association. Her current research interests include the human metabolism of carotenoids and dietary factors that produce/reduce oxidative stress. Her current projects include studies of the effect of tomato, lycopene, prune and vitamin E consumption on DNA damage and lipid peroxidation in patients with prostate cancer, diabetes or dyslipidemia.

Date:  Friday, January 25, 2002

Location:   Manzo's Banquets
1571 South Elmhurst Road
Des Plaines, IL 60018
847-593-2233


Topical Group Presentation

No Topical Group this month.


Social Hour: 6:00 PM - 7:00 PM -- cash bar
Dinner: 7:00 PM
Meeting: 8:00 PM

Cost:  $28.00 for members of ACS/ $30.00 for non-members/ $14.00 for students

Reservations:   (847) 647-8405
                    by noon, Tuesday, January 22

or,   REGISTER ON LINE !
Please honor your reservations. We must pay for all dinners ordered. No-shows will be billed.
Map and Directions:
From the East: Take I-90 west. Exit Elmhurst Rd North. Go past first light (Oakton St.). The banquet hall is on your right.

From the West: Take I-90 east. Exit Arlington Heights Rd. Turn right. Turn right. Go to Higgins Rd. (Rt. 72). Turn left. Take Higgins to Oakton St. Turn left. Go to Elmhurst Rd. Turn left. The banquet hall is on your right.

From the North: Take 294 south to I-90 west. Exit Elmhurst Rd. North. Go past first light (Oakton St.). The banquet hall is on your right.

From the South: Take 294 North to I-90 west. Exit Elmhurst Rd. North. Go past first light (Oakton St.). The banquet hall is on your right. Another way from the South is to take I-355 North to I-90 east. Exit Arlington Heights Rd. Turn right and go to Elmhurst Rd. Turn left. The banquet hall is on your right.

PARKING: Free


Dinner:

French Onion Soup
tossed salad with choice of Italian or French dressing
combination plate of New York Strip Steak and Chicken Breast Limone
Bruscetta salad
baked potato
rolls and butter
Crème De Menthe ice cream
beverage

Also available are a fish entrée (Orange Roughy) or vegetarian entrée (Pasta Primavera with a flavorful Marinara sauce) upon request at the time of reservation.





Updated 1/21/02