-- Wednesday, November 15, 2006 Meeting --
Joint with the University of Chicago Department of Chemistry
The Julius Stieglitz Award Lecture
Speaker:     Dr. Samuel Danishefsky
Professor of Chemistry, Columbia University;
Director of the bioorganic lab,
Sloan-Kettering Institute for Cancer Research
  Samuel Danishefsky
Topic:   "On the Power of Chemical Syntheses"  
Where: The Parthenon Restaurant
314 S. Halsted Street
Chicago, IL

Abstract:  As a consequence of major advances at the level of methodology, the power of the science of chemical synthesis has grown enormously. These huge advances in enabling reactions, often involving transition metal catalysts, have had a major impact on strategic planning in chemical synthesis. Structures hitherto perceived to be unavailable from a practical standpoint through chemical synthesis might, in fact, be quite available nowadays. 

Similarly, extraordinary advances in isolation techniques, purification techniques and above all assignment of structure to complex molecules have allowed for the identification and determination of exciting new natural products in very small-scale (milligrams or less). By combining these two advances with extraordinary advances in the science of screening for biological properties, the natural products field emerges in highly enhanced form as a potential resource in the discovery of new pharmaceutical agents of value. Regrettably, many Pharma organizations have seen fit to de-emphasize their involvement in Natural Products, just at the time when its prospects were the most promising ever.

In this lecture we show, by example, how advances in synthetic methodology, structure determination, and screening have created extraordinary opportunities for natural products as resources in the discovery of new drugs and vaccines.

Biography:   Samuel Danishefsky is a native of Bayonne, NJ, receiving his B.S.degree from Yeshiva University in 1956. He then attended Harvard, where he received his doctorate in 1962, later doing an NIH postdoctorate at Columbia University, from 1961-1963. He then spent 1964-1979 at the University of Pittsburgh, where he became University Professor in 1978.  He then went to Yale University, where he was Eugene Higgins Professor (1983-89) and Sterling Professor (1989-1993). In 1993, he returned to Columbia as professor of Chemistry, Eugene Kettering Professor, and director of the bioorganic laboratory of the Sloan - Kettering Institute for Cancer Research, a position that he holds presently.

He has received world-wide acclaim for his work in organic total synthesis of some of the most complex natural products, most of which are known to have significant physiological activity. Most of the syntheses require numerous stereoselective steps in order to obtain the desired stereospecificty.  Some of his most recent work -- an account of which was given recently in Chemical & Engineering News, Jan. 23, 2006, p. 7, -- described the synthesis of a telomerase inhibitor, known as UCS 1025A. Telomeres, telomerase and telomerase inhibitors are believed to be intimately involved in chromosomes, cancer, cell death and renewal, stem cells, ageing, i.e., some of life's most vital processes. Having a known inhibitor readily available will allow scientists to study these very important processes at the molecular level.

There are very few areas involving the synthesis of physiologically-active organic molecules that have not come under attack by Dr. Danishefsky at some time during his long and productive career: anti-tumor carbohydrate vaccines, several classes of anti-tumor chemotherapeutic agents, antibiotics, antivirals, angiogenesis agents, antiimmune agents, and on and on. In general, he is at the forefront of those approaches that blend the best chemical and biological science to obtain solutions to some of the most pressing problems of our time that involve disease treatment and prevention.

For his work and the more than six hundred publications that have resulted from it, he has received many awards, including most of the ACS Awards related to organic chemistry, including just to name a few, the Hudson Award in Carbohydrate Chemistry, Arthur Cope Scholar and Medal, the Guenther Prize, and the Aldrich Award for creative work in Organic Chemistry. He is a member of the National Academy of Sciences, the American Academy of Arts and Sciences and is a fellow of numerous foreign academies. He has received the Wolf prize in Chemistry, and has been chosen for many named lectures. It is in that role, as our Stieglitz Lecturer, that we welcome him on this occasion. We are indeed pleased and honored to have this most distinguished chemical scientist to come and speak to us.

A meeting of the Chicago Section JOB CLUB will be held at the Parthenon at 5:30 PM.   The JOB CLUB provides a continuing opportunity for unemployed members of the Section to meet one another, share their experiences and develop a network that may help in identifying employment opportunities.  Bring plenty of resumes and business cards to distribute to your colleagues.

The Job Club is also for employers seeking chemists.   Employers need to be prepared to describe the positions to be filled and requirements for these positions.

Should you wish to attend the Section meeting following the JOB CLUB, the fee for unemployed members is only $14 and you can continue your networking activities over dinner.  You can make your reservation on line, and indicate if you are unemployed to qualify for the discount.

Held at room 405, Columbia College of Chicago
Featuring Students from the Benedictine University

Date:  Wednesday, November 15, 2006

Undergraduate Research Symposium (at Columbia College):  4:00 PM - 5:00 PM
Job Club: 5:30 PM - 6:30 PM
Social Hour: 5:30 PM - 6:30 PM -- cash bar
Dinner: 6:30 PM   Note early start time for social hour and dinner!!
Presentation of Stieglitz Lecture: 8:00 PM

Cost:  $28.00 for members of ACS/ $30.00 for non-members/ $14.00 for students

Registration full.  Call the office at  (847) 647-8405 to be put on a waiting list.

   Please honor your reservations. We must pay for all dinners ordered. No-shows will be billed.

Map and Directions -- See map page.
PARKING: Free valet parking. Parking is also available on nearby streets or in a nearby pay lot.


Greek Family Style Dinner--

Appetizers: Saganaki (Kaseri cheese flamed in brandy), Gyros (roasted slices of lamb and beef), Taramosalata (fish roe blended with lemon and olive oil); traditional Greek salad.

Main course: Vegetarian Spinach-Cheese Pie, Vegetarian Pastitsio (Macaroni baked with broccoli, Bechamel sauce and Kefalotiri), Dolmades (vine leaves stuffed with rice, meats and herbs), Rotisserie-roasted lamb served with rice pilaf and roasted potatoes.

Desserts: Baklava (flaky layers of Phyllo baked with nuts and honey) and Galaktobouriko (flaky layers of Phyllo with vanilla custard and baked with syrup.

Updated 11/13/06