Location:	Ambassador Banquets 110 W. North Avenue Elmhurst, Illinois 60126

Cost:  $23.00 for members of ACS/ $25.00 for non-members

Reservations:   (847) 647-8405
                    by noon, Tuesday, January 18.

or,   REGISTER ON LINE !

Topical Group Meeting

Leanne de Muijnck
Research Manager, ADM Cocoa

DEVELOPMENT OF COLOR AND FLAVOR IN COCOA
            TASTE TEST- YOU DECIDE !
Click here for more information.

Social Hour: 6:00-7:00 PM
Dinner: 7:00 PM
Meeting: 8:00 PM

A convenient methodology for polymer-assisted solution-phase (PASP) chemical library synthesis and purification will be described. This approach applies fundamental properties of molecular recognition and/or molecular reactivity as the basis for a general purification strategy. Specifically, parallel solution-phase reactions are purified by the selective sequestration of reactants, byproducts, reagents, and catalysts by polymers containing complementary molecular recognition or molecular reactivity (CMR/R) functionality. When used in sequential or simultaneous combinations, various CMR/R polymers remove excess reactants, by-products, reagents, and reagent by-products from solution-phase reaction products, which are simply isolated in purified form by filtration. Where reactions involve the need to sequester byproducts or reagents that do not contain inherent, sequestrable functionality, sequestration can be effected by the design and use of tagged reactants or reagents containing artificially-imparted molecular recognition functionality. An extension of the PASP methodology is the use of a 'sequestration enabling reagent' (SER) which transforms reactants/reagents that do not contain a sequestrable functionality into a chemically tagged species capable of sequestration. More recent applications of PASP methodology include the use of a resin system that conveniently allows for oxidation reactions using periodinane reagents to be performed in a parallel format and its use in the preparation of an alpha-ketoamide library.

The PASP library synthesis and purification paradigm is general and highly amenable to automation. Several directed small molecule libraries have been generated utilizing the PASP methodology with automated workstations. Specific examples of the PASP strategy for library synthesis and product purification will be described.

John J. Parlow received his M.S. degree in synthetic organic chemistry in 1987 and his B.S. degree in chemistry in 1985, both from Miami University of Ohio. John joined the Monsanto Agricultural New Products Discovery Division in 1987 where he worked on the design and synthesis of small molecule inhibitors as herbicides and fungicides. In 1992, John was a founding member of the Combinatorial Chemistry effort within the Agricultural Division of Monsanto Corporation. His efforts in this endeavor were focused on solid and solution-phase organic synthesis of small molecule compound libraries resulting in the invention of Polymer-Assisted Solution-Phase (PASP) purification techniques and methodology. In 1996, he transferred to the Pharma sector of Monsanto Life Sciences to become a member of the Section of Medicinal and Combinatorial Chemistry within Searle Discovery Research. Mr. Parlow headed the Chemical Methodology Team advancing the development of solution-phase synthetic methodologies. He is presently involved in parallel/combinatorial chemistry for the use of discovering biologically active molecules. John is heavily involved in chemical library purification strategies which utilize complementary-functionalized resins as a purification technique for solution-phase synthesis.

From Downtown Chicago:
Take Eisenhower Expressway (290) West; exit at North Avenue (Route 64) westbound (exit 13B). Go west on North Avenue to the 3rd stoplight. The restaurant is located on the southwest corner of North Avenue and York Road.

From the West:
Take I-88 east to 355 north to North Avenue (Route 64) . Go east on North Avenue approximately 10 miles to York Road. The restaurant is located on the southwest corner of North Avenue and York Road.

From the North: Take Interstate 294 south to the exit marked "I-290 West/ U.S. 20-Lake/ Ill. 64- North Avenue". Exit immediately at "Ill 64-North Avenue" and proceed west to the restaurant at York Road.

Parking:   Free

Fruit Cup
Chef's tossed salad
roast sirloin
roasted chicken
homemade Italian sausage with mostaccioli
broccoli with Hollandaise
Greek oven-browned potatoes
rolls and butter
chocolate sundae
beverage
Fish entrée: (Orange roughy) is available upon request at the time of reservation.