From the City:
Take Interstate 55 South (towards St. Louis). Exit at South Cass Avenue. Proceed on Cass Avenue south one quarter mile to the Argonne Laboratory totem pole on the right. Turn right and proceed to the gate house and, after checking in, follow signs to the Argonne Guest House.
From the North:
Take Interstate 294 South to Interstate 55 South (towards St. Louis). Exit at South Cass Avenue. Proceed as above.